This Church was built in the 15th century next to an ancient hospital for the treatment of plague victims. Inside they are preserved two masterpieces of Umbrian Renaissance art. Pietro Vannucci, known as Perugino, frescoed “The martyrdom of St. Sebastian” (1505), where the geometric perspective gives life to an ideal space.  Few elegant figures populate the scene. Lake Trasimeno inspired the evocative landscape that forms the backdrop to the scene. The “Madonna with Child and musician angels” (early 16th century) is attributed to Raphael by Elvio Lunghi.  The painting depicts the Virgin and Child, four angels in concert on the sides  and the figures of Saints Augustine and Mary Magdalene kneeling below.  Mauro Staccioli also underlines the presence of the lake with  his “inverted arch” (1996) in corten steel at the beginning of Viale Belvedere.  5km from Panicale there is the Sanctuary of the Madonna di Mongiovino, which  is a magnificent example of Mannerist architecture and painting. According to the local tradition,  it arose on an aedicule that the Virgin, speaking to the shepherdess Andreana, asked to clean up; for testifying the divine intervention, Andreana was ordered to carry on her head a pitcher full of water in reverse and no drops fell.